[10000印刷√] il-23 psoriasis mouse model 256854

Il 23 Mediated Psoriasis Like Epidermal Hyperplasia Is Dependent On Il 17a The Journal Of Immunology

Introduction Psoriasis is a chronic, recurrent skin inflammatory condition that affects 23% of the world's population The disease is clinically characterized with the presence of scaly skin plaques, arthritis, and an inflammatory cellrich cutaneous microenvironment ()It is widely accepted that the interleukin (IL)23/IL17 axis plays a vital role in psoriasis development (), as It has been reported that high systemic levels of IL23 induce psoriasis and spondyloarthritis IL22 is required for Th17 cellmediated pathology in a mouse model of psoriasislike skin

Il-23 psoriasis mouse model

Il-23 psoriasis mouse model-Psoriasislike mouse model IL23treated resting macrophages express a distinctive gene expression prolife compared with M1 and M2 macrophages The identiﬁcation of IL23induced macrophage polarization may help us to understand the contribution of macrophage subpopulation in Th17cytokinesrelated pathogenesisIn psoriasis, IL23 plays an important role with genetic alterations of IL23p40 and IL23R leading to enhanced IL23 production increasing psoriasis susceptibility (5) and indeed injection of the IL17 supporting cytokine, IL23, into the skin of mice can induced psoriasislike inflammation (9)

Langerinneg Conventional Dendritic Cells Produce Il 23 To Drive Psoriatic Plaque Formation In Mice Pnas

Taken together, this system provides a useful mouse model for psoriasis and demonstrates distinct roles for IL23 and IL17 AB Psoriasis is an inflammatory disease with dynamic interactions between the immune system and the skinIntradermal injection of IL23 induced IL22 mediated, microbiota dependent psoriasislike inflammation in naïve SKG mice Conclusion In curdlantreated SKG mice IL23driven psoriasislike inflammation is induced in the setting of spondyloarthritis The skin inflammation recapitulates several features of human Ps and is dependent on the relative contributions of IL17, IL22,IL23 Psoriases model stimulates & promotes differentiation of Th17 cells Drives TH17 response by binding signaling through receptor subunits

IL23 production and a full psoriasislike skin phenotype, in germfree and RIGI knockout mice, and RIGI is also critical for a full development of skin inflammation in IMQinduced psoriasislike mouse model Furthermore, we identify that RIGImediated endogenous IL23 production is mainly confined to the CD11c dendriticConsequently, these models can be used in preclinical studies to investigate the molecular and cellular pathogenesis of psoriasis, as well as in the evaluation of potential therapies This article provides detailed methodologies for creating and evaluating the IL23 and Aldara/IMQinduced mouse models of psoriasisFACS analysis of skindraining lymph node cells from mice that were intradermally injected with IL23 revealed an increase in both IL22producing T cells and NK22 cells Taken together, this system provides a useful mouse model for psoriasis and demonstrates distinct roles for IL

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Psoriasis is an autoinflammatory skin disease of unknown etiology Topical application of Aldara cream containing the Tolllike receptor (TLR)7 agonist Imiquimod (IMQ) onto patients induces flares of psoriasis Likewise, in mice IMQ triggers pathological changes closely resembling psoriatic plaque formation Key cytokines like IL23 and typeI IFN (IFNI), both being IL23induced mouse model of psoriasis Mouse ears were injected intradermally with 500 ng recombinant mouse IL23 (IL23;

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